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DNA Life

Genetic research is at the forefront of clinical science. Few fields have reacted so positively to this progress than the practice of personalised medicine. Gene studies related to metabolism, lifestyle diseases, sports performance, and nutrition now make it possible to incorporate individual genetic responses into treatment protocols.  

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The impact of diet, lifestyle, exercise, and environment on our individual genetic makeup should not be underestimated. Knowledge of how genes are activated by external factors enables the development of highly effective, personalised treatments. Whether your patient suffers chronic disease or is at the apparent peak of fitness, a genetic profile can reveal the subtlest keys to proper treatment and training regimes.

DNA screening carried out by Nordic Lads

The Lab is called Nordic Labs.  For more info please visit:

http://nordiclabs.com/EProduct.aspx?id=123

Simon Bradley ND, NT (Dip CNM) is a certified DNA Life practitioner.

Knowing your unique self is the most important knowledge you will ever learn.

Many diseases are preventable through diet and lifestyle choices.

Better lifestyle and dietary choices can optimise energy, well being and overall health.

Middle-aged-People-exercising

DNA Health focuses upon 8 specific areas of metabolic function, each one providing functions that can influence a broad range of common conditions. Understanding the inter relationships and adapting diet and lifestyle can make real differences in the probability of disease development.

8 Genetic Factors

  • Cholesterol metabolism
  • DNA Methylation
  • Detoxification
  • Inflammation
  • Oxidative Stress
  • Insulin resistance
  • Bone health
  • Iron metabolism

29 Specific Genes

Cholesterol Metabolism

Certain genes influence LDL and HDL cholesterol levels and are associated with a higher risk of heart disease. Adaption with the right dietary choices to suit you can alter lipid profiles and influence the potential for cardio vascular disease.

  • Lipoprotein Lipase - LPL 1595 C>G
  • Cholesterol Ester Transfer Protein - CETP 279 G>A
  • Apolipoprotein C3 - APOC3 3175 C<g
  • Apolipoprotein E - APOE E2/E3/E4

DNA Methylation

B vitamins provide the building blocks for growing cells, they also supply some of the chemicals necessary for protecting our genes from damage from normal wear and tear in addition to turning genes on and off. The process of DNA repair is called methylation and B vitamins are a vital part of that process.

How effectively we can methylate or knowing the variants of active B group vitamins we personally require is central to natural growth and repair and the prevention of many common diseases.

  • Methylenetetrahydrofolate Reductase - MTHFR 677 C>T
  • Methylenetetrahydrofolate Reductase - MTHFR 1298 A>C
  • Methionine Synthase - MTR 2576 A>G
  • Catechol-O-Methyltransferase - COMT 472 G>A
  • Methionine Synthase Reductase - MTRR 66 A>G
  • Cystathionine Beta Synthase - CBS 699 C>T

Detoxification

The detoxification process in the body occurs mostly in two phases. Phase one enzymes are often called 'activators', as they change a substance that needs to be removed from the body into a form that phase two can complete efficiently and safely. Phase one activated substances are often potentially harmful to the body and other important factors must be in place to ensure harm is minimised. Phase two enzymes complete the detoxification process by making substances suitable for removal from the body.

  • Glutathione S Transferase M1 - GSTMI insertion / deletion
  • Glutathione S Transferase P1 - GSTPI 313 A>G
  • Glutathione S Transferase T1 - GSTT1 insertion / deletion
  • Cytochrome P450 1A1 - CYP Msp1 T>C
  • Cytochrome P450 1A1 - CYP ile462Val G>A

Inflammation

Inflammation is a normal immune response and an essential step in the healing process. The release of inflammatory substances is controlled by genes that govern inflammation but if they are over active or overly stimulated a cycle of low level systemic chronic inflammation can develop. A number of common conditions are associated with chronic inflammation including heart disease, arthritis, inflammatory bowel disease or obesity.

  • Interleukin 6 - il 6 174 G>C\
  • Tumour Necrosis Factor alpha - TNFA 308 G>A

Oxidative Stress

Free radicals are a normal by product of the body's energy generating biochemical processes. They are highly reactive with other molecules and can damage DNA, proteins and cellular membranes. Anti oxidants are free radical scavengers that interact with the free radical to ensure it is no longer a reactive molecule. Anti oxidants are found naturally in the body as certain enzymes but also from dietary sources.

  • Endothelial Nitric Oxide Synthase - eNOS 894 G>T
  • Manganese Superoxide Dismutase - SOD2 28 C>T
  • Superoxide Dismutase - SOD3 760 C>G

Insulin Sensitivity

With insulin resistance body cells have a diminished ability to respond to the action of the hormone insulin. Clusters of type 2 diabetes in certain families points to a strong genetic background for the disease, however environmental factors such as diet and lifestyle are often required for these genes to be active promote this condition.

  • Peroxisome Proliferator Activated Receptor gamma - PPARG Pro12Ala C>G
  • Transcription Factor 7 Like 2 - TCF7L2 T>C
  • Fat Mass and Obestity Associated Gene - FTO T>A

Bone Health

There is a strong genetic contribution of some 60-70% in the development of osteoporosis. The variance of bone mineral density can be accounted for by genetic variation and variations in diet

  • Vitamin D Receptor - VDR Fok1 T>C
  • Vitamin D Receptor - VDR BSM1 G>A
  • Vitamin D Receptor - VDR Taq1 C>T
  • Collagen 1A1 - COL1A1 1526 G>T

Iron Metabolism

Genetic variations in iron absorption can lead to a condition called haemochromoatosis. When absorption of iron from the intestines exceeds natural losses, iron can accumulate in the body leading to a variety of serious health condition. Thankfully the condition is treatable if detected early.

  • Hemochromotosis - HFE Cys282Tyr G>A
  • Hemochromotosis - HFE His63AAsp 187 C>G

Fact - You don't want to lose weight, you want to lose fat

Fact - Slimming clubs rely on you losing and regaining weight 

Fact - Slimming supplements are often expensive and may harm your health

If you are serious about losing fat, retaining or gaining lean muscle mass, losing viceral fat and keeping it off DNA Diet provides the information you need that will guide you for the rest of your life. 

For just £249 you will have an informative and lifelong guide to your weight management needs along with the personal support of a fully qualified Nutritional Therapist who will guide you through your test results and work with you to develop your personalised nutritional and lifestyle program. The total program gives you up to 2 hours consultation time and if you visit our offices in person a free body composition test worth £25 so you know exactly what you need to achieve and how to do it in a healthy and sustainable way.

You may purchase the test seperately from the consultation for £149 and this comes with a basic information guide to your results along with a simplified dietary and exercise program provided by Nordic Labs. 

For more information simply email This email address is being protected from spambots. You need JavaScript enabled to view it. 

or telephone 0121 523 1232 Monday to Saturday 10am to 6pm.

diet

Discover

  • How sensitive are you to carbohydrates
  • What type of fats suit you best
  • How to avoid regaining weight
  • How much exercise you really need to lose weight

If you struggle with weight loss then this test can provide a significant insight into the how to adapt diet and lifestyle in such a way that really works for you.

DNA Diet is the analysis of 13 well researched and clinically useful gene variations than impact obesity risk and weight loss.

8 Genetic factors that influence weight loss

  • Absorption and metabolism
  • Fat metabolism, obesity and satiety
  • Regulation of metabolism and feeding behaviour
  • Insulin sensitivity and regulation of energy intake
  • Exercise responsiveness
  • Circadian rhythms
  • Fat storage
  • Inflammation

13 Genes carefully selected due to their influence on weight management

  • Fatty Acid Binding Protein 2 - FABP2 Ala54Thr G>A
  • Peroxisome Proliferator Activated Receptor gamma - PPARG Pro12Ala C>G
  • Beta 2 Adrenergic Receptor - ADRB2 Arg16Gly G>A
  • Beta 2 Adrenergic Receptor - ADRB2 Gln27Glu C>G
  • Apolipoprotein A5 - APOA5 - 1131 T>C
  • Apolipoprotein A2 - APOA2 - 265 T>C
  • Melanocortin-4 Receptor - MC4R T>C
  • Fat Mass and Obesity Associated Gene - FTO rs9939609 T>A
  • Transcription Factor 7 Like 2 - TCF7L2 rs 7903146 C>T
  • Beta 3 Adrenergic Receptor - ADRB3 Trp64Arg T>C
  • Circadian Locomotor Output Cycles Kaput - Clock 3111 T>C
  • Perilipin - PLIN 11482 G>A
  • Tumour Necrosis Factor alpha - TNFA 308 G>A

Discover your true sporting potential

sport

Power and Endurance

Muscle fibre specialisation - are you best suited for strength or endurance.

Adaptability to training regimes, cardio-pulmonary capacity, blood pressure control, circulation and cardiac output all combine to reveal your real potential.

Injury

Building strength by adapting training to avoid injury.

Looking at genes that are involved in structural integrity of soft tissues in the body.

Recovery

Focusing upon the nutritional and recovery needs of the athlete.

Providing the right amount nutritional intervention to support inflammatory responses and pacing training patterns to allow adequate recovery suited to the individual.

The Genes (categories are general and crossover activity often occurs)

Blood Pressure Response

  • Angiotensinogen - AGT rs699 T>C
  • Angiotensin 1 Converting Enzyme - ACE insertion / deletion

VO2 max Potential and Mitochondrial biogenesis

  • Vascular Endothelial Growth Factor - VEGF 634 C>G
  • Nuclear Respiratory Factor 2 - NRF 2 rs7181866 A>G

Fluid and Electrolyte Requirements and Efficiency of Muscular Contraction

Bradykinin Receptor Beta 2 - BDKRB2 Rpt sequence exon 1 C>T

Strength and Endurance Potential

  • Alpha Actinin 3 - ACTN3 577 R/X
  • Vitamin D Receptor - VDR Taq1 T>C
  • Thyrotropin Releasing Hormone Receptor - TRHR rs16892496 T<g
  • Peroxisome Proliferator Activator Receptor alpha - PPARA Intron G>C
  • Peroxisome Proliferator Activated Receptor gamma Co Activator 1
  • - PPARGC1A Gly482Ser A>G
  • Beta 2 Adrenergic Receptor - ADRD 2 Arg16Gly A>G
  • Beta 2 Adrenergic Receptor - ADRB 2 Gln27Glu C>G

Potential for inflammation, fatigue and increased recovery times

  • Interleukin 6 Receptor - IL 6R Asp358Ala A>C
  • Interleukin 6 - IL6 174 G>C
  • C Reactive Protein - CRP 219 G>A
  • Tumour Necrosis Factor alpha - TNFA 308 G>A
  • Superoxide Dismutase 2 - SOD2 28 C>T

Injury and Recovery

  • Growth Differentiation Factor 5 - GDF5 rs143483 C>T
  • Collagen 1 Alpha 1 - COL1A1 rs1800012 G>T

Oestrogen metabolism plays an important role in both women's and mens lives.
Testing 6 genes with associations with oestrogen activity.

ostrogen

Testing for variations in a subgroup of genes helps to identify those with higher lifetime exposure to oestrogens, oestrogen metabolites and other carcinogens.

In many situations ensuring a sufficient level of appropriate nutrients that are specific to the individual can modulate synthesis, detoxification and excretion or oestrogen, helping to reduce the risk factors of oestrogen driven cancers.

Genetic Factors Evaluated

  • Efficiency of oestrogen synthesis
  • Efficiency of methylation
  • Efficiency of inactivating oestrogen
  • Evaluating over all production of less beneficial oestrogen metabolites

The Genes

  • Catechol O Methyltransferase - COMT 472 G>A
  • Sulfotransferase 1A1 - SULT1A1 638 G>A
  • Cytochrome P450 17A1 - CYP17A 34 T>C
  • Cytochrome P450 1A1 - CYP1A1 ile462Val A>G
  • Cytochrome P450 1A1 - CYP1A1 Msp1 6235 T>C
  • Cytochrome P450 1B1 - CYP1B1 1294 C>G

Osteoporosis, are you at risk?

50% of women and 20% of men will suffer a fracture after the age of 50

How Healthy are Your Arteries?

According to the British Heart Foundation cardiovascular disease, coronary heart disease and stroke accounted for nearly one third of all deaths in the UK in 2010

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